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Importance of DHA
What is DHA?
DHA and Early Brain Development
Researchers have previously shown that long-chain polyunsaturated fatty acids (LCPUFAs) play an important role in brain development1
Brain grows most rapidly from third trimester through 2 years of age 3
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Brain growth is 85% complete by age 33
DHA accretion in the brain increases rapidly during this time of rapid brain growth.
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Infants obtain DHA in utero primarily through preferential transfer of DHA through the placenta,5 with levels dependent on maternal supply6
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Following birth, infants receive DHA either through breast milk or formula1,7
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Worldwide levels of DHA in breast milk vary, with the average at about 0.32%8*
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Experts recommend DHA in early life to help support brain and eye development16
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Although DHA can be synthesized by the body from α-linolenic acid, the amount that an infant can synthesize may be limited
* Average level of DHA worldwide in breast milk is 0.32% + 0.22% (mean + standard deviation of total fatty acids) based on an analysis of 65 studies of 2474 women. 8
DHA helps support brain and eye development
Retinal function can be considered a “window to the brain.”
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In the developing embryo, the eye develops in close association with the brain; visual development requires a tight integration of retinal, neural pathway, and cortical function
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Visual development is, therefore, an extension of brain development, and visual acuity in infancy is one reflection of CNS development 2
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Since DHA concentrations in the retina and neural tissue are among the highest in the body, it is not surprising that DHA plays an important role in brain development 9
DHA in early life helps support cognitive development
A study published in 2013 involved 81 formula-fed children who were enrolled from birth and through 6 years.10
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Subjects had been randomized from birth through 12 months to receive one of 4 formulas:
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Control formula (no DHA/ARA)
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.32% DHA/.64% ARA
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.64% DHA/.64% ARA
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.96% DHA/.64% ARA
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Every 6-12 months, children were given age-appropriate cognition tests
Results revealed that:
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Infants fed formula that had 0.32% DHA had improved measures of executive function at 4 and 5 years and improved measures of verbal comprehension at 5 years compared to those who received the control formula.10
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These results demonstrate that DHA helps support cognitive development
DHA is important in preterm infants
For the preterm infant, the DHA accretion that occurs during the third trimester--when brain mass more than doubles--is abruptly interrupted.11-13
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Low blood levels of DHA have been associated with decreased respiratory health in preterm infants 14
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These infants, may benefit from DHA to support brain and retinal development, and to help support respiratory health 9
"Nutrition during early life is now recognized not only as a key determinant for immediate neonatal survival, growth, and mental development during infancy, but also as a major conditioning factor for long-term health.” – 2014 Global Expert Recommendations15
2014 Global Expert Recommendations for DHA: 16.4 mg – 55 mg per 100 kcal15
LCPUFA Supplementation and Configuration
Listen to Dr. John Colombo discuss the DIAMOND Study, a trial of LCPUFA postnatal dietary supplementation. This video will review the results of the study and examine cognitive development, testing, and how to properly interpret cognitive tests from infancy to early childhood.
John Colombo, PhD Professor of Psychology Director, Life Span Research Institute University of Kansas Lawrence, KS
ARA = arachidonic acid; DHA = docosahexaenoic acid; LCPUFA = long-chain polyunsaturated fatty acid
References