Products

    Nutramigen® (Liquids)

    Extensively hydrolyzed hypoallergenic liquid formula range for infants with cow’s milk allergy

    Indication

    Nutramigen is an iron-fortified, hypoallergenic infant formula designed for infants who are allergic to the intact proteins in cow’s milk and soy formulas. Nutramigen has extensively hydrolyzed casein protein to help avoid an immune response by reducing the allergen exposure and is proven effective for managing colic due to cow’s milk allergy.

    Product long term usage

    Nutramigen is designed to provide a sole source of nutrition for infants up to age 6 months, and provide a major source of nutrition through 12 months of age. Normally, in feeding infants, gradual introduction of solid foods after 4–6 months of age is an important developmental as well as nutritional step.

    In cases of continued food allergies or intolerances, Nutramigen is sometimes used as a milk substitute in the diet of children beyond 12 months of age. When Nutramigen is used as a milk substitute beyond 12 months of age, the total calcium content of the diet should be assessed.

    Extended use of Nutramigen (or other infant formulas) as a sole source of diet is most appropriately monitored by physicians and nutritionists on a case-by-case basis.

    Ingredients

    Ingredients: Ready to Use (2 fl oz Nursette® bottle): Water (87%), corn syrup solids (5%), vegetable oil (palm olein, soy, coconut and high oleic sunflower oils) (3%), casein hydrolysate* (milk) (2%), modified corn starch (2%) and less than 1%: Mortierella alpina oil, Schizochytrium sp. oil, carrageenan, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, calcium phosphate, magnesium oxide, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, sodium iodide, sodium selenite, sodium citrate, potassium citrate, potassium chloride, citric acid, taurine, L-cystine, L-tyrosine, L-tryptophan, L-carnitine.

    Ingredients: Ready To Use (6 fl oz Nursette bottle): Water (87%), corn syrup solids (5%), vegetable oil (palm olein, coconut, soy and high oleic sunflower oils) (4%), casein hydrolysate* (milk) (2%), modified corn starch (2%) and less than 1%: Mortierella alpina oil, Schizochytrium sp. oil, calcium phosphate, potassium citrate, calcium carbonate, potassium chloride, sodium citrate, magnesium oxide, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, sodium iodide, sodium selenite, carrageenan, choline chloride, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin hydrochloride, riboflavin, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, L-cystine, inositol, L-tyrosine, L-tryptophan, vitamin B12, taurine, L-carnitine.

    Ingredients: Ready To Use (8 fl oz bottle): Water (87%), corn syrup solids (5%), vegetable oil (palm olein, coconut, soy and high oleic sunflower oils) (3%), casein hydrolysate* (milk) (2%), modified corn starch (2%) and less than 1%: Mortierella alpina oil, Schizochytrium sp. oil, calcium phosphate, potassium citrate, calcium carbonate, potassium chloride, sodium citrate, magnesium oxide, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, sodium iodide, sodium selenite, carrageenan, citric acid, choline chloride, ascorbic acid, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin hydrochloride, riboflavin, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, L-cystine, inositol, L-tyrosine, L-tryptophan, vitamin B12, taurine, L-carnitine.

    Ingredients: Ready To Use (32 fl oz bottle): Water (87%), corn syrup solids (5%), vegetable oil (palm olein, soy, coconut, and high oleic sunflower oils) (4%), casein hydrolysate* (milk) (2%), modified corn starch (2%) and less than 1%: Mortierella alpina oil, Schizochytrium sp. oil, carrageenan, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, calcium phosphate, magnesium oxide, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, potassium iodide, sodium selenite, sodium citrate, potassium citrate, potassium chloride, citric acid, taurine, L-cystine, L-tyrosine, L-tryptophan, L-carnitine.

    Ingredients: Concentrate (13 fl oz can): Water (75%), corn syrup solids (10%), vegetable oil (palm olein, soy, coconut and high oleic sunflower oils) (7%), casein hydrolysate* (milk) (4%), modified corn starch (3%) and less than 1%: Mortierella alpina oil, Schizochytrium sp. oil, acetylated monoglycerides, carrageenan, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, calcium phosphate, magnesium oxide, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, sodium iodide, sodium selenite, sodium citrate, potassium citrate, potassium chloride, citric acid, taurine, L-cystine, L-tyrosine, L-tryptophan, L-carnitine.

    *Modified to be better tolerated in milk-allergic babies.
    A source of arachidonic acid (ARA).
    A source of docosahexaenoic acid (DHA).

    POTENTIAL ALLERGENS

    Nutramigen® contains milk and soy. Nutramigen is hypoallergenic. Rarely, however, allergic reactions to extensively hydrolyzed casein formulas have been reported.

    Nutrients

     

    (Normal Dilution)

    Per 100 Cal 2 fl oz RTU

    Per 100 Cal 6 fl oz RTU

    Per 100 Cal 8 fl oz RTU

    Per 100 Cal 13 fl oz Conc

    Per 100 Cal 32 fl oz RTU

    Per 100 mL 2 fl oz RTU

    Per 100 mL 6 fl oz RTU

    Per 100 mL 8 fl oz RTU

    Per 100 mL 13 fl oz Conc

    Per 100 mL 32 fl oz

    Protein, g

    2.8

    2.8

    2.8

    2.8

    2.8

    1.89

    1.89

    1.89

    1.89

    1.89

    Fat, g

    5.3

    5.3

    5.3

    5.3

    5.3

    3.6

    3.6

    3.6

    3.6

    3.6

    Linoleic acid, mg

    780

    780

    780

    780

    780

    530

    530

    530

    530

    530

    Carbohydrate, g

    10.3

    10.3

    10.3

    10.3

    10.3

    7

    7

    7

    7

    7

    Water, g

    131

    131

    131

    131

    131

    89

    89

    89

    89

    89

    Vitamins/Other Nutrients

                       

    Vitamin A, IU

    300

    300

    300

    300

    300

    200

    200

    200

    200

    200

    Vitamin D, IU

    60

    60

    60

    60

    60

    41

    41

    41

    41

    41

    Vitamin E, IU

    2

    2

    2

    2

    2

    1.35

    1.35

    1.35

    1.35

    1.35

    Vitamin K, mcg

    9

    9

    9

    9

    9

    6.1

    6.1

    6.1

    6.1

    6.1

    Thiamin (Vitamin B1), mcg

    80

    80

    80

    80

    80

    54

    54

    54

    54

    54

    Riboflavin (Vitamin B2), mcg

    90

    90

    90

    90

    90

    61

    61

    61

    61

    61

    Vitamin B6, mcg

    60

    60

    60

    60

    41

    41

    41

    41

    41

    41

    Vitamin B12, mcg

    0.3

    0.3

    0.3

    0.3

    0.3

    0.2

    0.2

    0.2

    0.2

    0.2

    Niacin, mcg

    1000

    1000

    1000

    1000

    1000

    680

    680

    680

    680

    680

    Folic acid (Folacin), mcg

    16

    16

    16

    16

    16

    10.8

    10.8

    10.8

    10.8

    10.8

    Pantothenic acid, mcg

    500

    500

    500

    500

    500

    340

    340

    340

    340

    340

    Biotin, mcg

    3

    3

    3

    3

    3

    2

    2

    2

    2

    2

    Vitamin C (Ascorbic acid), mg

    12

    12

    12

    12

    12

    8.1

    8.1

    8.1

    8.1

    8.1

    Choline, mg

    24

    24

    24

    24

    24

    16.2

    16.2

    16.2

    16.2

    16.2

    Inositol, mg

    24

    24

    24

    24

    24

    16.2

    16.2

    16.2

    16.2

    16.2

    Minerals

                       

    Calcium, mg

    94

    94

    94

    94

    94

    64

    64

    64

    64

    64

    Phosphorus, mg

    52

    52

    52

    52

    52

    35

    35

    35

    35

    35

    Magnesium, mg

    8

    8

    8

    8

    8

    5.4

    5.4

    5.4

    5.4

    5.4

    Iron, mg

    1.8

    1.8

    1.8

    1.8

    1.8

    1.22

    1.22

    1.22

    1.22

    1.22

    Zinc, mg

    1

    1

    1

    1

    1

    0.68

    0.68

    0.68

    0.68

    0.68

    Manganese, mcg

    25

    25

    25

    25

    25

    16.9

    16.9

    16.9

    16.9

    16.9

    Copper, mcg

    75

    75

    75

    75

    75

    51

    51

    51

    51

    51

    Iodine, mcg

    15

    15

    15

    15

    15

    10.1

    10.1

    10.1

    10.1

    10.1

    Selenium, mcg

    2.8

    2.8

    2.8

    2.8

    2.8

    1.89

    1.89

    1.89

    1.89

    1.89

    Sodium, mg

    47

    47

    47

    47

    47

    32

    32

    32

    32

    32

    Potassium, mg

    110

    110

    110

    110

    110

    74

    74

    74

    74

    74

    Chloride, mg

    86

    86

    86

    86

    86

    58

    58

    58

    58

    58

    Product nutrient values and ingredients are subject to change. Please see product label for current information

    Nutrient Density

    20 Cal/fl oz 2 & 6 fl oz

    20 Cal/fl oz 13 fl oz

    20 Cal/fl oz 8 & 32 fl oz

     

    RTF

    Concentrate

    RTF

    Protein (% Calories)

    11

    11

    11

    Fat (% Calories)

    48

    48

    48

    Carbohydrate (% Calories)

    41

    41

    41

    Potential Renal Solute Load (mOsm/100 Calories)1

    25

    25

    25

    Potential Renal Solute Load (mOsm/100 mL)1

    16.9

    16.9

    16.9

    Osmolality (mOsm/kg water)

    320

    260

    270

    Osmolarity (mOsm/L)

    280

    230

    240

    Lactose-Free

    Yes

    Yes

    Yes

    AMINO ACID COMPOSITION

    ESSENTIAL AMINO ACIDS

    mg/100 Cal

    Histidine

    84

    Isoleucine

    162

    Leucine

    270

    Lysine

    240

    Methionine

    73

    Cysteine

    48

    Phenylalanine

    137

    Tyrosine

    59

    Threonine

    129

    Tryptophan

    46

    Valine

    200

    NONESSENTIAL AMINO ACIDS

    mg/100 Cal

    Arginine

    112

    Alanine

    95

    Aspartic Acid

    210

    Glutamic Acid

    640

    Glycine

    59

    Proline

    290

    Serine

    162

    Product Forms and Ordering Information

    NUTRAMIGEN IS AVAILABLE IN READY-TO-FEED LIQUID AND CONCENTRATE

    Coding systems and reimbursement allowable rates vary by payer:

    • Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
    • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
    • Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

    Nutramigen®, Concentrate (13 fl oz can)
    Item #: 049811
    Description: Concentrate
    Unit Size: 13 fl oz can
    Calories/Unit: 520
    Product Yield/Unit (fl oz): 26
    Case: 12 cans per case
    HCPCS Code: B4161
    NDC Format Code: 00087-0498-01

    Nutramigen®, Ready-to-Feed (2 fl oz Nursette® bottle)
    Item #: 143701
    Description: RTF
    Unit Size: 2 fl oz bottle
    Calories/Unit: 40
    Product Yield/Unit (fl oz): 2
    Case: 48 bottles per case
    HCPCS Code: B4161
    NDC Format Code: 00087-1437-41

    Nutramigen®, Ready-to-Feed (6 fl oz Nursette® bottle)
    Item #: 429704
    Description: RTF
    Unit Size: 6 fl oz bottle
    Calories/Unit: 120
    Product Yield/Unit (fl oz): 6
    Case: 24 bottles per case
    HCPCS Code: B4161
    NDC Format Code: 00087-5105-17

    Nutramigen®, Ready-to-Feed (32 fl oz bottle)
    Item #: 169101
    Description: RTF
    Unit Size: 32 fl oz bottle
    Calories/Unit: 640
    Product Yield/Unit (fl oz): 32
    Case: 6 bottles per case
    HCPCS Code: B4161
    NDC Format Code: 00087-5115-64

    PRODUCT BENEFITS

    Nutramigen is clinically proven to quickly manage colic due to cow’s milk allergy

    • Starts to manage colic in as early as the first feeding, with 90% of infants improving within 48 hours*,1

    Nutramigen is a hypoallergenic liquid formula that has DHA at the same clinically proven amount as the worldwide breast milk average†,2

    • DHA at 0.32% of total fatty acids
    • Has DHA and ARA to support brain & eye development3-10

    Additional product features:

    • Hypoallergenic protein source (extensively hydrolyzed casein)
    • Clinically proven to effectively manage colic due to cow's milk allergy in 48 hours2-3*
    • Nutritionally complete
    • DHA and ARA, important nutrients also found in breast milk that promote brain and eye development4-11
    • Fatty acid profile patterned after breast milk12-13
    • Lactose-free

    *Studied before the addition of DHA and ARA.
    Comparison based on fatty acid profile of typical mature U.S. breast milk.

    LETTER OF MEDICAL NECESSITY FOR NUTRAMIGEN

    This letter establishes a medical need for Nutramigen and might help parents get reimbursed by their insurance company for the product

    Contact Mead Johnson

    Contact a Mead Johnson representative to request information and samples

    Layout:
    Understanding Cow’s Milk Allergy (CMA)
    Review the impact of CMA and the additional research Mead Johnson has supported to improve outcomes for infants with food allergies.
    Help parents receive supplemental nutrition approved formulas
    Special Supplemental Nutrition Program for Women, Infants, and Children
    Additional products for cow’s milk allergy
    Mead Johnson has a complete portfolio for infants and toddlers with CMA and food allergies.

    *WIC is a registered trademark of the United States Department of Agriculture (USDA) for the
    Women, Infants, & Children Program. No endorsement of any brand or product by the USDA is implied
    or intended.

    References

    1. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.
    2. Lothe L, Lindberg T. Cow’s milk whey protein elicits symptoms of infantile colic in colicky formula-fed infants: a double-blind crossover study. Pediatrics. 1989;83:262-266.
    3. Brenna JT, Varamini B, Jensen RG, et al. Docosahexanoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007:85:1457-1464.
    4. Birch EE, Hoffman DR, Uauy RD, et al. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res. 1998;44:201-209.
    5. Birch EE, Garfield S, Hoffman DR, et al. A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol. 2000;42:174-181.
    6. Birch EE, Hoffman DR, Castañeda YS, et al. A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age. Am J Clin Nutr. 2002;75:570-580.
    7. Hoffman DR, Birch EE, Castañeda YS, et al. Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial. J Pediatr. 2003;142:669-677.
    8. Hoffman DR, Birch EE, Castañeda YS, et al. Maturation of visual and mental function in 18-month-old infants receiving dietary long-chain polyunsaturated fatty acids (LCPUFAs) [abstract]. FASEB J. 2003;17:A727-A728. Abstract 445.1.
    9. Hoffman DR, Birch EE, Birch DG, et al. Impact of early dietary intake and blood lipid composition of long-chain polyunsaturated fatty acids on later visual development. J Pediatr Gastroenterol Nutr.2000;31:540-553.
    10. Birch EE, Castañeda YS, Wheaton DH, et al. Visual maturation of term infants fed long-chain polyunsaturated fatty acid-supplemented or control formula for 12 mo. Am J Clin Nutr. 2005;81:871-879.
    11. Morale SE, Hoffman DR, Castañeda YS, et al. Duration of long-chain polyunsaturated fatty acids availability in the diet and visual acuity. Early Hum Dev. 2005;81:197-203.
    12. Innis SM. Human milk and formula fatty acids. J Pediatr. 1992;120(suppl): S56-S61.
    13. Jensen RG, ed. Handbook of Milk Composition. San Diego, Calif: Academic Press;1995.