Products

HCY 1

An iron-fortified infant formula and medical food powder for infants and young children with documented homocystinuria

Indication

HCY 1 is an iron-fortified infant formula and medical food powder that is free of the essential amino acid methionine for infants and young children with documented homocystinuria. The product has all other essential amino acids as well as nonessential amino acids, carbohydrates, fats, essential fatty acids, vitamins and minerals. Use under direct and continuing medical supervision.

Ingredients

Ingredients:Corn syrup solids, vegetable oil (palm olein oil, coconut oil, soy oil, high oleic sunflower oil), amino acids (L-glutamine, L-leucine, potassium aspartate, L-lysine hydrochloride, L-proline, L-valine, L-isoleucine, L-alanine, L-arginine, L-threonine, L-phenylalanine, L-tyrosine, L-serine, L-cystine, glycine, L-histidine, L-tryptophan), modified corn starch, sugar, calcium phosphate and less than 1%: Mortierella alpina oil*, Crypthecodinium cohnii oil†, ethyl vanillin, sodium citrate, potassium citrate, magnesium oxide, ferrous sulfate, potassium chloride, zinc sulfate, cupric sulfate, manganese sulfate, sodium iodide, sodium selenite), choline chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, vitamin B6 hydrochloride, thiamin hydrochloride, riboflavin, vitamin D3, folic acid, biotin, vitamin K₁, vitamin E acetate, vitamin A palmitate, vitamin B₁₂, taurine, L-carnitine.

*A source of arachidonic acid (ARA).

†A source of docosahexaenoic acid (DHA).

Nutrients

	Per 100 grams Powder
Calories	500
Protein equivalent, g*	16.2
Fat, g	26
Linoleic acid, mg	4000
Carbohydrate, g	51
Vitamins/Other Nutrients
Vitamin A, IU	1520
Vitamin D, IU	380
Vitamin E, IU	10
Vitamin K, mcg	40
Thiamin (Vitamin B₁), mcg	1000
Riboflavin (Vitamin B₂), mcg	1000
Vitamin B₆, mcg	1000
Vitamin B₁₂, mcg	2
Niacin, mcg	10000
Folic acid (Folacin), mcg	100
Pantothenic acid, mcg	3800
Biotin, mcg	38
Vitamin C (Ascorbic acid), mg	60
Choline, mg	124
Inositol, mg	86
Minerals
Calcium, mg	660
Phosphorus, mg	440
Magnesium, mg	66
Iron, mg	9.6
Zinc, mg	8.6
Manganese, mcg	380
Copper, mcg	860
Iodine, mcg	76
Selenium, mcg	14.1
Sodium, mg	240
Potassium, mg	560
Chloride, mg	430

Product nutrient values and ingredients are subject to change. Please see product label for current information.

Protein Equivalent (% Calories)^*	13
Fat (% Calories)	47
Carbohydrate (% Calories)	40
Potential Renal Solute Load (mOsm/100 g powder)³	144
Osmolality (mOsm/kg water)^†	350
Osmolarity (mOsm/L)^†	320
Lactose-free	Suitable for someone with lactose intolerance

*WARNING: Protein is incomplete since it does not contain the essential amino acid methionine..

†Determined at 20 Cal/fl oz dilution.

AMINO ACID COMPOSITION

ESSENTIAL AMINO ACIDS	mg/100 g powder
Histidine	410
Isoleucine	1150
Leucine	2100
Lysine	1310
Methionine	0
Cysteine	600
Phenylalanine	680
Tyrosine	680
Threonine	760
Tryptophan	310
Valine	1260

NONESSENTIAL AMINO ACIDS	mg/100 g powder
Arginine	990
Alanine	1070
Aspartic Acid	1300
Glutamine	2600
Glycine	580
Proline	1300
Serine	650

Dilutions and Preparation

DILUTION INFORMATION FOR HCY 1

Mixing instructions by calories, measures and displacement

Download dilution information

POWDER

A child’s health depends on carefully following the instructions below. Proper hygiene, preparation, dilution, use and storage are important when preparing product. Powdered products are not sterile and should NOT be fed to premature infants or persons who might have immune problems unless directed and supervised by a child’s medical professional.

Discuss with parents whether they need to use cooled, boiled water for mixing and whether they need to boil clean utensils, bottles and nipples in water before use.

The medical professional will provide instructions for the correct amounts of water and powder. Pour the required amount of water into the bottle/container. Add the correct amount of powder, cap the bottle/container and shake vigorously.

If instructed to use the scoop in the can, each unpacked, level scoop delivers approximately 4.5 g of powder. Store DRY scoop in can.

Failure to follow these instructions could result in severe harm. Once prepared, product can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use prepared product if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared product. After feeding begins, use product within 1 hour or discard.

WARNING: Do not use a microwave oven to warm product. Serious burns may result.

Refer to the product label for the most accurate information.

CAUTION: Mead Johnson Nutrition HCY 1 is to be used only in the dietary management of infants and young children with documented homocystinuria while under direct and continuing medical supervision.

WARNING: This product is nutritionally incomplete. Care must be taken to provide enough methionine to support growth using other foods with this amino acid as required. Medical professionals must carefully and constantly supervise use of HCY 1 with other foods and liquids and adjust the diet based on frequent blood tests.

WARNING: Not for parenteral (I.V.) use.

Powder Storage: Store cans at room temperature. After opening can, keep tightly covered, store in a dry area and use contents within 1 month. Do not freeze powder and avoid excessive heat.

Use by date on bottom of can.

Product Forms and Ordering Information

HCY 1 IS AVAILABE IN POWDER

When using this information, please note the following:

Coding systems and reimbursement allowable rates vary by payer:

Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

HCY 1, Powder
Item #: 893301
Description: Powder
Unit Size: 1 lb can
Calories/Unit: 2270
Product Yield/Unit (fl oz): Varies
Case: 6 cans per case
HCPCS Code: B4162
NDC Format Code: 00087-5102-02

PRODUCT BENEFITS

HCY 1 has all the essential amino acids for babies and young children with documented homocystinuria, as well as nonessential amino acids, carbohydrates, fats, essential fatty acids, vitamins and minerals

DHA and ARA
Methionine-free
Has choline, an essential nutrient important for brain development and the normal functioning of cells^1,2
Has cystine
Increased levels of B vitamins, compared to routine infant formulas, for cofactor production
• Vitamin and mineral levels meet the U.S. Infant Formula Act requirements per 100 Calories

Additional product features:

Vanilla scent
Mixes easily and stays in suspension well
Halal

Letter of Medical Necessity HCY 1

This letter establishes a medical need for HCY 1 and might help get your patients' insurance company to reimburse them for the product.

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Increase dietary compliance with motivational interviewing

Use this toolkit to help incorporate motivational interviewing when counselling your patients and caregivers affected by metabolic disorders.

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Contact Mead Johnson

Contact a Mead Johnson representative to request information and samples

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Free metabolic starter kit

Receive a starter case of metabolic product for your newly diagnosed patients.

Help parents receive Special Supplemental Nutrition Program for Women, Infants, and Children

Access your state’s medical documentation form to help your patients

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References

Food and Nutrition Board, Institute of Medicine, Choline. In: Dietary References Intakes for Thiamin, Riboflavin, Niacin, Vitamin B₆, Folate, Vitamin B₁₂, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academies Press;1998:390-422.
Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev.2009;67:615-623.
Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr.1999;134:11-14.