Products

    Enfamil® Reguline®

    Milk-based infant formula designed to support digestive health and promote soft stools with our exclusive Natural Defense® Dual Prebiotic blend

    Indication

    Enfamil Reguline is a 20 Cal/fl oz infant formula specifically designed to help support digestive health and promote soft, comfortable stools in 1 week.* It is designed to be fed when stooling issues, such as occasional difficult bowel movements, are causes of parental concern. Enfamil Reguline has our exclusive Natural Defense Dual Prebiotic blend that works like fiber to promote soft stools within 1 week and for as long as the baby consumes the formula. Enfamil Reguline has easy-to-digest proteins that are partially hydrolyzed.

    Product long term usage

    Enfamil Reguline is designed to provide the sole source of nutrition for infants up to age 6 months and provide a major source of nutrition for the remainder of the first year.

    Enfamil Reguline can be used as an everyday formula throughout an infant’s first year of life.

    *Proven in Enfamil® Infant formula.

    Ingredients

    Ingredients: Partially hydrolyzed nonfat milk and whey protein concentrate solids (soy), vegetable oil (palm olein, coconut, soy and high oleic sunflower oils), corn syrup solids, lactose and less than 2%: polydextrose,* galactooligosaccharides,* Mortierella alpina oil, Crypthecodinium cohnii oil, vitamin A palmitate, vitamin D3, vitamin E acetate, vitamin K1, thiamin hydrochloride, riboflavin, vitamin B6 hydrochloride, vitamin B12, niacinamide, folic acid, calcium pantothenate, biotin, ascorbic acid, choline chloride, inositol, calcium carbonate, calcium phosphate, magnesium phosphate, ferrous sulfate, zinc sulfate, manganese sulfate, cupric sulfate, sodium selenite, sodium citrate, potassium chloride, potassium iodide, taurine, L-carnitine.

    *A type of prebiotic.
    †A source of arachidonic acid (ARA).
    ‡A source of docosahexaenoic acid (DHA).

    POTENTIAL ALLERGENS

    Enfamil Reguline contains milk and soy.

    Nutrients

    (Normal Dilution)

    Per 100 Calories (5 fl oz)

    Per 100 mL

    Per 100 grams (Powder 510 Cal)

    Protein, g

    2.3

    1.55

    11.7

    Fat, g

    5.3

    3.6

    27

    Linoleic acid, mg

    780

    530

    4000

    Carbohydrate, g

    11.1

    7.5

    56

    Water, g

    133

    90

    2.4

    Vitamins/Other Nutrients

         

    Vitamin A, IU

    300

    200

    1520

    Vitamin D, IU

    60

    41

    300

    Vitamin E, IU

    2

    1.35

    10.2

    Vitamin K, mcg

    9

    6.1

    46

    Thiamin (Vitamin B1), mcg

    80

    54

    410

    Riboflavin (Vitamin B2), mcg

    140

    95

    710

    Vitamin B6, mcg

    60

    41

    300

    Vitamin B12, mcg

    0.3

    0.2

    1.52

    Niacin, mcg

    1000

    680

    5100

    Folic acid (Folacin), mcg

    16

    10.8

    81

    Pantothenic acid, mcg

    500

    340

    2500

    Biotin, mcg

    3

    2

    15.2

    Vitamin C (Ascorbic acid), mg

    12

    8.1

    61

    Choline, mg

    24

    16.2

    122

    Inositol, mg

    6

    4.1

    30

    Minerals

     

    Calcium, mg

    82

    55

    420

    Phosphorus, mg

    46

    31

    230

    Magnesium, mg

    8

    5.4

    41

    Iron, mg

    1.5

    1.01

    7.6

    Zinc, mg

    1

    0.68

    5.1

    Manganese, mcg

    15

    10.1

    76

    Copper, mcg

    75

    51

    380

    Iodine, mcg

    15

    10.1

    76

    Selenium, mcg

    2.8

    1.89

    14.2

    Sodium, mg

    36

    24

    183

    Potassium, mg

    108

    73

    550

    Chloride, mg

    63

    43

    320

    Product nutrient values and ingredients are subject to change. Please see product label for current information.

    Nutrient Density

    20 Calories/fl oz

    Protein (% Calories)

    9

    Whey:Casein Ratio

    60:40

    Fat (% Calories)

    48

    Carbohydrate (% Calories)

    43

    Potential Renal Solute Load (mOsm/100 Calories)10

    21

    Potential Renal Solute Load (mOsm/100 mL)10

    14

    Osmolality (mOsm/kg water)

    250

    Osmolarity (mOsm/L)

    230

    Lactose-free

    No

    AMINO ACID COMPOSITION

    ESSENTIAL AMINO ACIDS

    mg/100 Cal

    mg/100 g Pwd

    Histidine

    58

    290

    Isoleucine

    133

    680

    Leucine

    250

    1250

    Lysine

    210

    1050

    Methionine

    53

    270

    Cysteine

    42

    210

    Phenylalanine

    97

    490

    Tyrosine

    92

    470

    Threonine

    140

    710

    Tryptophan

    40

    200

    Valine

    140

    710

    NONESSENTIAL AMINO ACIDS

    mg/100 Cal

    mg/100 g Pwd

    Arginine

    69

    350

    Alanine

    101

    510

    Aspartic Acid

    230

    1150

    Glutamic Acid

    460

    2300

    Glycine

    46

    230

    Proline

    184

    940

    Serine

    131

    670

    Product Forms and Ordering Information

    ENFAMIL REGULINE IS AVAILABLE IN POWDER

    Coding systems and reimbursement allowable rates vary by payer:

    • Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
    • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
    • Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

    Enfamil® Reguline®, Powder (12.4 oz can)
    Item #: 167002
    Description: Powder
    Unit Size: 12.4 oz can
    Calories/Unit: 1800
    Product Yield/Unit (fl oz): 90
    Case: 6 cans per case
    HCPCS Code: B4158
    NDC Format Code: 00087-5111-32

    Enfamil® Reguline®, Powder (20.4 oz tub)
    Item #: 167004
    Description: Powder
    Unit Size: 20.4 oz tub
    Calories/Unit: 2940
    Product Yield/Unit (fl oz): 147
    Case: 4 tubs per case
    HCPCS Code: B4158
    NDC Format Code: 00087-5111-57

    PRODUCT BENEFITS

    Enfamil Reguline is easy to digest and clinically proven to soften stools within 1 week*1

    • Easy-to-digest proteins that are partially hydrolyzed
    • 50% of carbohydrates from lactose

    Exclusive Natural Defense Dual Prebiotic blend clinically proven to promote beneficial bacteria in the digestive tract and help support digestive health*1-3

    • Promotes soft stools similar to those reported for breastfed infants4

    Proprietary patented Triple Health Guard® blend of brain-nourishing DHA, Natural Defense Dual Prebiotic blend designed to support immune health and 30 nutrients for growth

    • Complete nutrition appropriate for infants to continue feeding through 12 months of age to help support digestive health throughout the first year

    Clinically proven DHA at 0.32% of total fatty acids, the same amount as the worldwide breast milk average‡4

    DHA is:

    • Clinically proven to support mental, visual and immune system development5–8
    • Clinically shown to improve long-term cognitive outcomes through 5 years of age†9
    • Shown to improve respiratory health through the first 3 years of life when infants were fed through 12 months†5

    Enfamil NeuroPro Infant has not been shown superior to the leading competitor in supporting mental, visual and immune system development in infants. The level of DHA in Similac Pro-Advance is ~0.15% of total fatty acids.

    Additional product features:

    • Kosher

    *Proven in Enfamil® Infant formula
    †Studies compared infants fed Enfamil® with DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.
    ‡Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women.5

    HELP PARENTS CONCERNED ABOUT THEIR BABY'S BOWEL MOVEMENTS

    Share this pamphlet with parents who are looking for information on comfortable stooling.

    Contact Mead Johnson

    Contact a Mead Johnson representative to request information and samples

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    References

    1. Ashley C, Johnston WH, Harris CL, et al. Growth and tolerance of infants fed formula supplemented with polydextrose (PDX) and/or galactooligosaccharides (GOS): double-blind, randomized, controlled trial. Nutr J. 2012:11:38.
    2. Salminen S et al. Early Gut Colonization With Lactobacilli and Staphylococcus in Infants: The Hygiene Hypothesis Extended. J Pediatr Gastroenterol Nutr. 2016;62(1):80-86.
    3. Scalabrin D et al. New Prebiotic Blend of Polydextrose and Galacto-oligosaccharides Has a Bifidogenic Effect in Young Infants. J Pediatr Gastroenterol Nutr. 2012;54(3):343-352.
    4. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.
    5. Birch EE, Khoury JC, Berseth CL, et al. The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children. J Pediatr. 2010;156:902-906.
    6. Birch EE, Hoffman DR, Uauy R, et al. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res. 1998;44:201-209.
    7. Birch EE, Garfield S, Hoffman DR, et al. A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol. 2000;42:174-181.
    8. Morale SE, Hoffman DR, Castaneda YS, et al. Duration of long-chain polyunsaturated fatty acids availability in the diet and visual acuity. Early Hum Dev. 2005;81:197-203.
    9. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.
    10. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.