Products

    Enfamil® Enspire™ Gentlease®

    Designed to reduce fussiness, gas and crying.

    Indication

    Enfamil Enspire Gentlease is a 20 Cal/fl oz milk-based, iron-fortified infant formula designed to ease fussiness, gas and crying. Enfamil Enspire Gentlease is the trusted Gentlease formula, designed to reduce fussiness, gas and crying in 24 hours1,*, now has MFGM and lactoferrin. MFGM and lactoferrin are two ingredients previously only found in breast milk: MFGM to foster cognitive development and lactoferrin to support immune health.

    Product long term usage

    Enfamil Enspire Gentlease is designed to have the sole source of nutrition for infants up to age 6 months and a major source of nutrition for the remainder of the first year.

    Ingredients

    Ingredients: Powder: Corn syrup solids, vegetable oil (palm olein, coconut, soy and high oleic sunflower oils), partially hydrolyzed nonfat milk and whey protein concentrate solids (soy), whey protein-lipid concentrate (milk)**, and less than 2%: Lactoferrin, Mortierella alpina oil††, Schizochytrium sp. oil‡‡, sodium citrate, calcium phosphate, potassium chloride, calcium carbonate, magnesium phosphate, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, potassium iodide, sodium selenite, soy lecithin, choline chloride, inositol, ascorbic acid, niacinamide, calcium pantothenate, riboflavin, thiamin hydrochloride, vitamin D3, vitamin B6 hydrochloride, folic acid, vitamin K1, biotin, vitamin B12, vitamin E acetate, vitamin A palmitate, taurine, L-carnitine.

    ** A source of MFGM (milk fat globule membrane).
    †† A source of arachidonic acid (ARA).
    ‡‡ A source of docosahexaenoic acid (DHA).

    POTENTIAL ALLERGENS

    Enfamil Enspire Gentlease contains milk and soy.

    Nutrients

    (Normal Dilution)

    Per 100 Calories
    (5 fl oz)

    Per 100 mL Powder

    Per 100 grams Powder
    (510 Cal)

    Protein, g

    2.3

    1.56

    11.5

    Fat, g

    5.3

    3.6

    27

    Linoleic acid, mg

    780

    530

    3900

    Carbohydrate, g

    10.8

    7.3

    54

    Water, g

    133

    90

    2.4

    Vitamins/Other Nutrients

         

    Vitamin A, IU

    300

    200

    1500

    Vitamin D, IU

    70

    47

    350

    Vitamin E, IU

    2

    1.35

    10

    Vitamin K, mcg

    9

    6.1

    45

    Thiamin (Vitamin B1,), mcg

    80

    54

    400

    Riboflavin (Vitamin B2,), mcg

    140

    95

    700

    Vitamin B6, mcg

    60

    41

    300

    Vitamin B12, mcg

    0.3

    0.2

    1.5

    Niacin, mcg

    1000

    680

    5000

    Folic acid (Folacin), mcg

    16

    10.8

    80

    Pantothenic acid, mcg

    500

    340

    2500

    Biotin, mcg

    3

    2

    15

    Vitamin C (Ascorbic acid), mg

    12

    8.1

    60

    Choline, mg

    24

    16.2

    120

    Inositol, mg

    24

    16.2

    120

    Minerals

         

    Calcium, mg

    82

    55

    410

    Phosphorus, mg

    46

    31

    230

    Magnesium, mg

    8

    5.4

    40

    Iron, mg

    1.8

    1.22

    9

    Zinc, mg

    1

    0.68

    5

    Manganese, mcg

    15

    10.1

    75

    Copper, mcg

    75

    51

    380

    Iodine, mcg

    15

    10.1

    75

    Selenium, mcg

    2.8

    1.89

    14

    Sodium, mg

    40

    27

    200

    Potassium, mg

    108

    73

    540

    Chloride, mg

    63

    43

    320

     

    Product nutrient values and ingredients are subject to change. Please see product label for current information.

    Nutrient Density

    20 Calories/fl oz

    Protein (% Calories)

    9

    Whey:Casein Ratio

     

    Fat (% Calories)

    48

    Carbohydrate (% Calories)

    43

    Potential Renal Solute Load (mOsm/100 Calories)8

    21

    Potential Renal Solute Load (mOsm/100 mL)8

    14.2

    Osmolality (mOsm/kg water)

    210

    Osmolarity (mOsm/L)

     

    Lactose-free

    No

    Galactose-Free

    No

    Product Forms and Ordering Information

    ENFAMIL ENSPIRE GENTLEASE IS AVAILABLE IN POWDER AND READY-TO-FEED LIQUID

    Coding systems and reimbursement allowable rates vary by payer:

    • Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
    • Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information

    Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

    Enfamil® Enspire™ Gentlease®, Powder (19.5 oz tub)
    Item #: 172804
    Description: Powder
    Unit Size: 19.5 oz can
    Calories/Unit: 2900
    Product Yield/Unit (fl oz): 145
    Case: 4 tubs per case
    HCPCS Code: B4158**
    NDC Format Code: 00087-5123-53

    Enfamil® Enspire™ Gentlease®, Powder Refill (29 oz box)
    Item #: 172802
    Description: Powder, Refill
    Unit Size: 29 oz box
    Calories/Unit: 4200
    Product Yield/Unit (fl oz): 210
    Case: 4 boxes per case
    HCPCS Code: B4158**
    NDC Format Code: 00087-5123-55

    ** HCPCS application is in progress.

    PRODUCT BENEFITS

    Enfamil Enspire Gentlease

    • Milk fat globule membrane (MFGM) provides brain-building benefits and is show to support cognitive outcomes at 12 months2
    • Lactoferrin, a key protein also in colostrum and breast milk, helps support immune health3
    • Designed to have an easy-to-digest protein blend of MFGM and partially hydrolyzed protein
    • Has ingredients clinically shown to reduce fussiness, gas and crying in 24 hours1,*
    • Infant formula that has MFGM and DHA is clinically shown to be a safe and well-tolerated source of nutrition2
    • DHA at the clinically proven amount of 0.32% of total fatty acids, the same amount as the worldwide breast milk average4,§, and double the amount found in the leading competitor's product||:
      • Clinically shown to support cognitive and visual development5
      • Clinically shown to improve long-term cognitive outcomes through 5 years of age6,‡

    Additional product features:

    • Inositol at the average amount found in breast milk
    • Non-GMO#
    • Kosher

    * Studied before the reformulation of Gentlease
    In amounts supported by clinical research
    Studies compared infants fed Enfamil® that had DHA and ARA vs. discontinued Enfamil without DHA and ARA; studied before the addition of prebiotics.
    § Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women4.
    || Enfamil Enspire Gentlease has not been shown superior to the leading competitor in supporting mental, visual and immune system development in infants. The level of DHA in Siliac Pro-Advance™ is ~0.15% of total fatty acids.
    The global average total inositol level in mature breast milk over the course of lactation is 22 mg/100 kcal7.
    # Ingredients not genetically engineered. Trace amounts of genetically engineered material may be present in the product, such as from manufacturing environments and process sources. For more information, visit enfamil.com/nonGMO.

    References

    1. Berseth CL, Johnston WH, Stolz SI, et al. Clinical response to 2 commonly used switch formulas occurs within 1 day. Clin Pediatr (Phila). 2009;48:58-65
    2. Timby N, Domellöf E, Hernell O, et al. Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy; low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr. 2014;99:860-868
    3. King JC Jr, Cummings GE, Guo N, et al. A double-blind, placebo-controlled, pilot study of bovine lactoferrin supplementation in bottle-fed infants. J Pediatr Gastroenterol Nutr. 2007;44:245-251.
    4. Brenna JT, Varamiini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr. 2007;85:1457-1464.
    5. Birch EE, Garfield S, Castañeda Y, et al. Visual acuity and cognitive outcomes at 4 years of age in a double-blind, randomized trial of long-chain polyunsaturated fatty acid-supplemented infant formula. Early Hum Dev. 2007;83:279-284.
    6. Colombo J, Carlson SE, Cheatham CL, et al. Long-term effects of LCPUFA supplementation on childhood cognitive outcomes. Am J Clin Nutr. 2013;98:403-412.
    7. Data on file.
    8. Fomon SJ, Zieglar EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.