Products

Enfamil^®Premature 20 Cal/fl oz

Milk-based infant formula with 20 Calories/fl oz for premature or low birth weight infants who are not being breastfed

Indication

Enfamil Premature 20 Cal/fl oz is a milk-based infant formula specifically formulated to meet the unique nutritional needs of rapidly growing premature or low birth weight infants who do not receive human milk.* The Enfamil Premature Nutrition portfolio is the only premature infant formula line designed to meet the latest Global Expert Recommendations for all labeled nutrients. Protein is a major driver of lean mass growth and neuro-cognitive outcomes, and Enfamil Premature Nutrition supports these protein needs.

Additional Usage Guidelines

When more than 14 fl oz (414 mL) of 20 Calories/fl oz product is used per day, which may occur in larger infants weighing over 2500 g (5.5 lbs) consuming only Enfamil Premature, intake of some nutrients (eg, fat soluble vitamins) may be excessive. In such circumstances, it should be used only at the direction and under the supervision of a doctor. Enfamil^® NeuroPro EnfaCare^® may be a product to consider in such circumstances.

*Increased caloric density, protein and some vitamins and minerals compared to standard term formula to help support weight and growth in babies born prematurely.

Ingredients

Ingredients: Ready To Feed (2 fl oz Nursette bottles): Water, nonfat milk, corn syrup solids, whey protein concentrate, lactose, medium chain triglycerides (MCT oil), soy oil, high oleic sunflower oil and less than 0.5%: Mortierella alpina oil^*, Crypthecodinium cohnii oil^†, calcium phosphate, calcium hydroxide, potassium citrate, sodium chloride, calcium carbonate, magnesium phosphate, calcium chloride, potassium chloride, ferrous sulfate, zinc sulfate, cupric sulfate, potassium iodide, sodium selenite, rice starch, sodium ascorbate, vitamin E acetate, niacinamide, calcium pantothenate, vitamin A palmitate, thiamin hydrochloride, riboflavin, vitamin B₆ hydrochloride, folic acid, vitamin K₁, biotin, vitamin B₁₂, mono- and diglycerides, inositol, soy lecithin, choline chloride, vitamin D₃, nucleotides (cytidine 5’-monophosphate, disodium uridine 5’-monophosphate, adenosine 5’-monophosphate, disodium guanosine 5’-monophosphate), taurine, L-carnitine.

*A source of arachidonic acid (ARA).

†A source of docosahexaenoic acid (DHA).

POTENTIAL ALLERGENS

Enfamil Premature 20 Cal/fl oz contains milk and soy

Nutrients

(Normal Dilution)	Per 100 Calories	Per 100 mL
Protein, g	3.3	2.2
Fat, g	5	3.4
Linoleic acid, mg	810	550
Carbohydrate, g	10.8	7.3
Water, g	132	89
Vitamins/Other Nutrients
Vitamin A, IU	1350	910
Vitamin D, IU	300	200
Vitamin E, IU	6.3	4.3
Vitamin K, mcg	9	6.1
Thiamin (Vitamin B₁), mcg	200	135
Riboflavin (Vitamin B₂), mcg	300	200
Vitamin B₆, mcg	150	101
Vitamin B₁₂, mcg	0.25	0.17
Niacin, mcg	4000	2700
Folic acid (Folacin), mcg	40	27
Pantothenic acid, mcg	1200	810
Biotin, mcg	4	2.7
Vitamin C (Ascorbic acid), mg	20	13.5
Choline, mg	24	16.2
Inositol, mg	44	30
Minerals
Calcium, mg	165	112
Phosphorus, mg	90	61
Magnesium, mg	9	6.1
Iron, mg	1.8	1.22
Zinc, mg	1.5	1.01
Manganese, mcg	6.3	4.3
Copper, mcg	120	81
Iodine, mcg	25	16.9
Selenium, mcg	5	3.4
Sodium, mg	70	47
Potassium, mg	98	66
Chloride, mg	106	72

Product nutrient values and ingredients are subject to change.

Nutrient Density	20 Calories/fl oz
Protein (% Calories)	13
Whey:Casein Ratio	80:20
Fat (% Calories)	44
Carbohydrate (% Calories)	43
Potential Renal Solute Load (mOsm/100 Calories)⁹	30
Potential Renal Solute Load (mOsm/100 mL)⁹	20
Osmolality (mOsm/kg water)	260
Osmolarity (mOsm/L)	230
Lactose-free	No

AMINO ACID COMPOSITION

ESSENTIAL AMINO ACIDS	mg/100 Cal	mg/100 mL Lig
Histidine	76	51
Isoleucine	200	134
Leucine	360	240
Lysine	310	200
Methionine	73	48
Cysteine	76	51
Phenylalanine	125	84
Tyrosine	116	77
Threonine	230	152
Tryptophan	64	42
Valine	200	134

NONESSENTIAL AMINO ACIDS	mg/100 Cal	mg/100 mL Lig
Arginine	92	62
Alanine	162	108
Aspartic Acid	350	240
Glutamic Acid	640	430
Glycine	66	44
Proline	230	156
Serine	188	125

Feeding Options and Preparation

FEEDING INFORMATION FOR ENFAMIL PREMATURE 20 CAL/FL OZ

Guidelines for alternate feeding needs

Download dilution information

NURSETTE^® BOTTLES

A baby’s health depends on carefully following the instructions below. Use only as directed by a medical professional. Proper hygiene, preparation, dilution, use and storage are important when preparing infant formula.

2 fl oz Bottles

Inspect each bottle for signs of damage.
Wash hands thoroughly with soap and water before preparing bottle for feeding.
SHAKE BOTTLE WELL and remove cap. Attach nipple unit (not included).

Failure to follow these instructions could result in severe harm. Opened bottles can spoil quickly. Either feed immediately or cover and store in refrigerator at 35–40°F (2–4°C) for no longer than 24 hours. Do not use opened bottle if it is unrefrigerated for more than a total of 2 hours. Do not freeze. After feeding begins, use formula within 1 hour or discard.

Warning: Do not use a microwave oven to warm formula. Serious burns may result.

Storage: Store unopened bottles at room temperature. Avoid excessive heat and prolonged exposure to light. Do not freeze.

THIS PRODUCT SHOULD BE USED ONLY AS DIRECTED BY THE BABY’S DOCTOR.

USE BY DATE ON CARTON AND BOTTLE LABEL.

DO NOT USE IF CAP RING IS BROKEN OR MISSING.

DO NOT ACCEPT IF PACKAGE HAS BEEN OPENED

Product Forms and Ordering Information

ENFAMIL^® PREMATURE 20 Cal/fl oz IS AVAILABLE IN READY-TO-FEED NURSETTE^® BOTTLES

When using this information, please note the following:

Coding systems and reimbursement allowable rates vary by payer:

Medicare Part B uses HCPCS (Healthcare Common Procedure Coding System) to group products
Medicaid systems vary by state; some use HCPCS while others use NDC format code or systems of their own—contact your state provider for more information
Private health insurance and managed care companies may use HCPCS, NDC format code or their own system—contact your provider for more information

Enfamil^® Premature 20 Cal/fl oz, Ready-to-Feed
Item #: 156401
Description: RTF, 20 Cal/fl oz
Unit Size: 2 fl oz bottle
Calories/Unit: 40
Product Yield/Unit (fl oz): 2
Case: 48 bottles per case
HCPCS Code: B4160
NDC Format Code: 00087-5115-70

PRODUCT BENEFITS

Enfamil Premature 20 Cal/fl oz is specifically formulated to meet the unique nutritional needs of rapidly growing premature or low birth weight infants

3 g of protein/100 Calories—appropriate for growth and development^1-3
Fat blend is 40% medium-chain triglycerides (MCT) oil to promote fat absorption^4,5
Carbohydrate blend of 60% corn syrup solids (glucose polymers) and 40% lactose that is easily digested and helps avoid overloading the premature infant's capacity to digest lactose
Provides approximately 2 mg iron/kg body weight when fed at 120 Cal/kg body weight per day
80:20 whey-to-casein ratio patterned after early human milk*

In a multicenter study, 64% of preterm infants had low vitamin D^†concentrations at birth⁶

Meets the 2014 Global Expert Recommendations for all labeled nutrients, including vitamin D¹

Calcium, phosphorus and vitamin D within the ranges recommended by experts to help support bone mineralization and growth¹:
- Calcium:phosphorus ratio = 1.83:1
DHA at 0.34% of total fatty acids, similar to the worldwide breast milk average^‡7, to help support brain and eye development and to help support blood DHA concentration⁸

Additional product features:

Kosher, Halal

*Whey-to-casein ratio 3-5 days after lactation begins.
†Serum 25 (OH) D concentrations <50 nmol/L at birth.
‡Average amount of DHA in worldwide breast milk is 0.32% ± 0.22% (mean ± standard deviation of total fatty acids) based on an analysis of 65 studies of 2,474 women.⁷

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References

Koletzko B, Poindexter B, Uauy R (eds). Nutritional Care of Preterm Infants: Scientific Basis and Practice Guidelines. World Rev Nutr Diet.Basel, Karger, 2014; 110:1-314.
Klein CJ. Nutrient requirements for preterm infant formulas. J Nutr.2002;132(suppl):1395S-1577S.
Agostoni C, Buonocore G, Carnielli VP, et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr.2010;50:85-91.
Tantibhedhyangkul P, Hashim SA. Medium-chain triglyceride feeding in premature infants: effects on fat and nitrogen absorption. 1975;55:359-370.
Andrews BF, Lorch V. Improved fat and Ca absorption in LBW infants fed a medium-chain triglyceride containing formula [abstract]. Pediatr Res.1974;8:104.
Monangi N et al. Vitamin D status of early preterm infants and the effects of vitamin D intake during hospital stay Arch Dis Child Fetal Neonatal Ed. 2014;99:F166-F168.
Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr.2007;85:1457-1464.
Innis SM, Adamkin DH, Hall RT, et al. Docosahexaenoic acid and arachidonic acid enhance growth with no adverse effects in preterm infants fed formula. J Pediatr.2002;140:547-554.
Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.

Enfamil®Premature 20 Cal/fl oz